Denamarin/Denosyl Liver Health Supplement

Denamarin is the #1 vet recommended liver support brand for dogs and cats. It is clinically proven combination of powerful antioxidants to support the liver and brain.

Denamarin provides multi-faceted high-level nutritional support for the liver due to its synergistic combination of S-adenosylmethionine (SAMe) and silybin.

When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly. Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione, ^{1, 2} an important compound for liver health formed when SAMe is metabolized. The SAMe in Denamarin has also been shown to help protect liver cells from cell death ^{3, 4} and may help cell repair and regeneration. ⁵

Denamarin also helps support your pet's liver through the administration of SILYBIN. SILYBIN is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance.

While best known for supporting the liver in dogs and cats, research has shown that the S-Adenosylmethionine (SAMe) in Denamarin may help support cognitive function in dogs ⁶. Denamarin provides SAMe in a stabilized form to help with brain health and act as a neuroprotector. Denamarin also provides a bioavailable form of silybin which supports oxidative balance.

Denamarin has no known side-effects. Your veterinarian can evaluate the length of support needed through follow-up examinations, blood work, and/or other laboratory work. At home, watch for a reponse in your pet's attitude, appetite, and activity level.

What can Denamarin be used for ?

Denamarin is sold exclusively through veterinary suppliers (vet clinics and pet pharmacies) as adjunctive treatment for liver disease or dysfunction, such as the following:

• Chronic hepatitis
• Hepatic lipidosis
• Cholangiohepatitis
• Paracetamol toxicity
• Corticosteroid use (Note: does not prevent corticosteroid induced hepatic vacuolar change)
• Other acute or chronic hepatopathies, including hepatotoxins and neoplasia.

Dosage:

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulty administering tablets to their pets, Denamarin tablet(s) may be disguised in a small bite of food. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.